Sponsorship Bias in the Comparative Efficacy of Psychotherapy and Pharmacotherapy for Adult Depression: Meta-Analysis

BACKGROUND: Sponsorship bias has never been investigated for non-pharmacological treatments like psychotherapy.

AIMS: We examined industry funding and author financial conflict of interest (COI) in randomised controlled trials directly comparing psychotherapy and pharmacotherapy in depression.

METHOD: We conducted a meta-analysis with subgroup comparisons for industry v. non-industry-funded trials, and respectively for trial reports with author financial COI v. those without.

RESULTS: In total, 45 studies were included. In most analyses, pharmacotherapy consistently showed significant effectiveness over psychotherapy, g = -0.11 (95% CI -0.21 to -0.02) in industry-funded trials. Differences between industry and non-industry-funded trials were significant, a result only partly confirmed in sensitivity analyses. We identified five instances where authors of the original article had not reported financial COI.

CONCLUSIONS: Industry-funded trials for depression appear to subtly favour pharmacotherapy over psychotherapy. Disclosure of all financial ties with the pharmaceutical industry should be encouraged.

Get Full Text: Journal site


© The Royal College of Psychiatrists 2017.

PubMed: 27810891

DOI: 10.1192/bjp.bp.115.179275


Source: https://www.ncbi.nlm.nih.gov/labs/articles/27810891/

Subscribe To Our Newsletter

Get updates in your inbox

Related posts:

More Bad News About Benzos

(Medscape) – Hello. I’m Dr Arefa Cassoobhoy, a practicing internist, Medscape advisor, and senior medical director for WebMD. Benzodiazepines are in the news again—this time,

Read More »

Leave a Reply

Your email address will not be published. Required fields are marked *

Join The Movement

Subscribe now to join us on our mission to create better mental health care for all.