Rationale and design of an international randomized placebo-controlled trial of a 36-ingredient micronutrient supplement for children with ADHD and irritable mood: The Micronutrients for ADHD in Youth (MADDY) study
Attention-Deficit/Hyperactivity Disorder (ADHD) is a chronic neurodevelopmental disorder
affecting up to 9% of children and substantial numbers of adults. Existing pharmacologic treatments often
improve symptoms, but concerns exist over side effects, stigma, potential long-term health effects, and residual
irritability, often treated with adjunctive antipsychotics. To address public and clinician demand for nonpharmacologic evidence-based treatments, this study will examine efficacy of a 36-ingredient micronutrient
(vitamin/mineral) supplement as treatment for children with ADHD and irritability.